Improving the Multi-Threaded upload performance
If you enabled the Multi-Threaded option for your upload, you will notice a significant improvement in the speed of your uploads. Starting from 10.0.7.238, the Connection limit and the Nagle Algorithm are already incorporated within Add-ins and it will decide on the values and when to use it to improve upload performance.
When multi-threaded upload is enabled, it is recommended for Data Response Timeout to have a value between 300 to 600 seconds. This can be done by changing the settings in the User Preferences.