Different endpoint for reply
Consider this data flow for request document:
A --> Process.SalesOrder --> B 
Application A sends a Process.SalesOrder to
      application B:
- Implicit routing 
Application B sends an
Acknowledge.SalesOrderto application A. Application A can or cannot handle the response. - Explicit routing 
You can model an additional data flow for reply:
B --> Acknowledge.SalesOrder --> CApplication B sends
Acknowledge.SalesOrderto Application C. Application C accepts the acknowledge.